Clinical Index

Literature Review

Over the last 5 years there has been exponential growth of clinical investigations and evidence shown of NovoSorb BTM. A literature review of 172 publications, the vast majority independent of PolyNovo, was conducted to better understand the performance of NovoSorb BTM in the hands of numerous surgeons across the globe.

To assess performance, an analysis of all publications (released by 2022) was conducted with the following inclusion criteria: underwent peer-review, contained published data, did not overlap previously published data, included endpoints of BTM take, skin graft take, and/ or number of applications. 50 publications met the criteria (3 of 50 sponsored by PolyNovo) and all 241 NovoSorb BTM patients in the publications were included.

Table 1: NovoSorb BTM Publication Growth

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New Standard Results:

Avg.94%

NovoSorb BTM Take

Avg.98%

Skin Graft Take

Within1

Application

Table 2: NovoSorb BTM Scar Assessment

Scaled 1-10, 1 representing best scar or sensation, 10 being worst
Scaled 1-10, 1 representing normal skin, 10 being very different to normal skin

NovoSorb BTM has been clinically evaluated by globally recognized scar assessment scales. Table 2 illustrates 5 publications (3 being prospective) where POSAS was used to assess the scar quality of NovoSorb BTM treated wounds (n=74) in 48 patients. Scoring was conducted 12 months post skin graft in all studies except Li et al. where follow-up time ranged from 3-18 months.²⁷ Reported are the observers overall scores with an average of 2.80 out of 10.

Download Clinical Index

Clinical Summary of Select Publications

Author/Year	Description	Wounds Evaluated	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings
Author/Year Wu et al. 2022¹¹	Description Retrospective review of all patients treated with NovoSorb BTM (PolyNovo) or CCS bilayer (Integra Life Sciences) between January 31, 2015 through July 31st, 2020. 303 cases are reviewed and 206 are excluded based on inclusion criteria. <18 years of age (n=47), multiple types of dermal matrices used (n=128), no dermal matrix applied (n=14), or deceased within study period (n=17). Clinical outcomes are compared between BTM group (n=51) and CCS (n=46).	Wounds Evaluated 51	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Statistically significant results include: skin graft loss (BTM 3.6% vs CCS 23.1%), skin graft complications (BTM 25% vs CCS 37.5%), mean number of secondary procedures (BTM 1.0 vs CCS 1.9), mean number of skin grafts applied (BTM 1.1 vs 1.5 CCS), use of NPWT (31.4% BTM vs 60.9% CCS), concomitant treatments at surgical site (41.2% BTM vs 67.4% CCS) and time to skin graft (BTM 37 days vs 16 days CCS); however, time to definitive closure is not statistically different (5.4 months BTM vs 6.4 months CCS).
Author/Year Li et al. 2021²⁷	Description Multcenter prospective study.	Wounds Evaluated 35	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Average 97% BTM take and 88% skin graft take. POSAS scale evaluation demonstrated 3.63 ± 2.04 (1 being normal skin, 10 being very different to normal skin).
Author/Year Patel et al. 2022²⁴	Description Near total scalp avulsion (80%) missing pericranium following dog bite of pediatric patient. BTM applied following failed Integra Bilayer Wound Matrix.	Wounds Evaluated 1	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Complete take of BTM and subsequent skin graft with no signs of infection and a “favorable aesthetic and sensory outcome” at 6 months.
Author/Year Solanki et al. 2022¹⁶	Description 72% of wounds include exposed bone or tendon.	Wounds Evaluated 25	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Skin graft take is “excellent and complete in most cases.” Range of motion (ROM) is considered “excellent with no skin tethering.” Study limitations include lacking long term follow up.
Author/Year Carrington-Windo et al. 2021³⁷	Description Traumatic injury to chest at high risk of infection.	Wounds Evaluated 1	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings No infection despite contaminated wound. Excellent cosmetic and functional outcome. Includes patient perspective.
Author/Year Schlottmann et al. 2022³⁸	Description Single-centre retrospective analysis of patients with multiple co-morbidities.	Wounds Evaluated 27	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Fastest integration is 13 days with a mean of 23.5 days. BTM shows high tolerance against infection with 18 of 20 patients having colonized wounds at time of BTM application.
Author/Year Shah et al. 2022²⁹	Description First report using sequential layering of BTM to improve resulting skin contour.	Wounds Evaluated 1	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings 100% BTM and subsequent skin graft take at 14 days post BTM application. Includes patient perspective.
Author/Year Teelucksingh et al. 2022	Description Pediatric trauma with compound fractures and degloving where BTM used with free flaps	Wounds Evaluated 2	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Very complex traumatic injuries. Demonstrates use of external fixator through integrated BTM. BTM used to supplement insufficient wound coverage by latissimus dorsi myocutaneous flap. Immediate BTM application was a useful adjunct to free tissue transfer and soft tissue reconstruction in a wound that traditionally would have been managed with autograft alone.
Author/Year Wagstaff et al. 2015¹²	Description Prospective case series of free-flap (fibular and radial forearm) donor site reconstructions.	Wounds Evaluated 10	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings 100% BTM and subsequent skin graft take for every patient who survived (1 died early for unrelated reasons). POSAS and MAPS scores are reported. Histology of punch biopsies showed degradation is virtually complete by 12 months, other than occasional microscopic remnants undergoing phagocytosis.
Author/Year Damkat-Thomas et al. 2019⁸	Description First report of traumatic degloving case treated using BTM. 72-yearold diabetic man with hypertension and obesity.	Wounds Evaluated 1	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Early signs of vascularization on Day 4 post BTM application. Ultrasound scan at 16 months demonstrated EHL and extensor tendons gliding freely under BTM without evidence of tethering. Mature pliable stable tissue with full ROM of toes extensors achieved.
Author/Year Wagstaff et al. 2019¹⁹	Description First published case series of BTM for necrotizing fasciitis, including over extensive exposed bone and tendon.	Wounds Evaluated 8	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings 99% BTM take and 100% skin graft take within a single application. “BTM also has a beneficial role in necrotizing fasciitis defects.”
Author/Year Sun et al. 2021³⁹	Description Largest (15 cm) skin cancer (BCC) excision case reported to date.	Wounds Evaluated 1	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings 100% BTM and skin graft take. Excellent cosmetic and functional outcome.
Author/Year Kuang et al. 2022³³	Description First prospective study evaluating the use of BTM for complex diabetic foot wounds.	Wounds Evaluated 18	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Thirteen of 18 patients completed BTM treatment regime with patients achieving complete wound healing at a median time of 13 weeks. The rate of infection and reulceration are relatively low for this high-risk population at 15.4%. BTM demonstrates potential in healing diabetic foot wounds with exposed deep structures and chronic wounds subject to high shear stress.
Author/Year Jennings et al. 2021¹⁷	Description First published case of severe meningococcal septicaemia.	Wounds Evaluated 8	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings 100% BTM take and 98.33% skin graft take. “[BTM] may possess a higher degree of bacterial resistance than biological alternatives.”
Author/Year Crowley et al. 2020²¹	Description 9-year-old sustained extensive degloving injuries, in difficult anatomical wound areas, following motor vehicle trauma.	Wounds Evaluated 7	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings 100% BTM take with supple tissue and an acceptable cosmetic result.
Author/Year Schmitt et al. 2021²⁶	Description Early physical therapy (PT) exercises reported with BTM.	Wounds Evaluated 20	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings Establishes guidance on mobilization post BTM application. POSAS and MAPS indicated good cosmetic outcomes with relatively low levels of itch and minimal pain at 12 months after injury.
Author/Year MacDiarmid et al. 2022	Description Lower limb reconstruction following large circumferential resection of a giant Marjolin’s ulcer.	Wounds Evaluated 1	Trauma	Reconstruction	Soft Tissue Infection	Chronic Wounds	Cancer Resection	Pressure Wounds	Limb Salvage	Donor Site	Exposed Bone/Tendon	Upper Extremity	Lower Extremity	Head/Neck	Trunk	Key Findings 100% BTM take and 95% skin graft take. Authors record great cosmetic and functional outcome.

Published articles

Carrington-Windo E, Leong S, Ibrahim N, Pope-Jones S. 2021

Biodegradeable temporising matrix use in a traumatic chest wound.

Concannon E, Damkat-Thomas L, Rose E, Coghlan P, Solanki N, Wagstaff M. 2023

Use of a synthetic dermal matrix for reconstruction of 55 patients with non-graftable wounds and management of complications.

Crowley K, Balaji S, Stalewski H, Carroll D, Mariyappa-Rathnamma B. 2020

Use of Biodegradable Temporizing Matrix (BTM) in large trauma induced soft tissue injury: A two stage repair.

Damkat-Thomas L, Greenwood JE, Wagstaff MJD. 2019

A synthetic Biodegradable Temporising Matrix in degloving lower extremity trauma reconstruction: A case report.

Li H, Lim P, Stanley E, Lee G, Lin S, Neoh D, Liew J, Ng SK. 2021

Experience with NovoSorb^® Biodegradable Temporising Matrix in reconstruction of complex wounds.

Patel NK, Tipps JA, Graham EM, Taylor JA, Mendenhal SD. 2022

Reconstruction of a near-total scalp avulsion with NovoSorb Biodegradable Temporizing Matrix: Pediatric case report.

Storey K, Lalloz M, Choy K-T, McBride CA, McMillan C, Das Gupta R, Patel B, Choo K, Stefanutti G, Borzi P, Phua Y, Bade S, Griffin B, Kimble RM. 2023

The versatility of Biodegradable Temporising Matrix – A 63 paediatric case series with complex wounds.

Teelucksingh S, Chang C, Henton J, Lewis CJ. 2022

Immediate application of Biodegradable Temporizing Matrix to a muscle free flap for complex soft tissue reconstruction.

Saha S. 2021

Minimalistic reconstruction of exposed skull in a complex craniovertebral polytrauma.

Saha S. 2021

Tissue engineered successful reconstruction of a complex traumatized lower extremity.

Saha S. 2022

Minimally invasive successful reconstruction of a severely traumatized upper extremity using plateletrich plasma and tissue scaffold: A case report.

Schlottmann F, Obed D, Bingöl AS, März V, Vogt PM, Krezdorn N. 2022

Treatment of complex wounds with NovoSorb^® Biodegradable Temporising Matrix (BTM) — A retrospective analysis of clinical outcomes.

Solanki NS, York B, Gao Y, Baker P, Wong She RB. 2020

A consecutive case series of defects reconstructed using NovoSorb^® Biodegradable Temporising Matrix: Initial experience and early results.

Wu SS, Wells M, Ascha M, Gatherwright J, Chepla K. 2022

Performance of Biodegradable Temporizing Matrix vs collagen-chondroitin silicone bilayer dermal regeneration substitutes in soft tissue wound healing: a retrospective analysis.

MacDiarmid S, Butler D. 2022

Biodegradable Temporising Matrix for lower limb reconstruction following the resection of giant Marjolin’s ulcer.

Schlottmann F, Obed D, Bingöl AS, März V, Vogt PM, Krezdorn N. 2022

Treatment of complex wounds with NovoSorb^® Biodegradable Temporising Matrix (BTM) — A retrospective analysis of clinical outcomes

Wu SS, Wells M, Ascha M, Gatherwright J, Chepla K. 2022

Performance of Biodegradable Temporizing Matrix vs collagen-chondroitin silicone bilayer dermal regeneration substitutes in soft tissue wound healing: a retrospective analysis.

Wu SS, Wells M, Ascha M, Gatherwright J, Chepla KJ. 2022

Upper extremity wounds treated with Biodegradable Temporizing Matrix vs collagen-chondroitin silicone bilayer

Shah R, Kiely A, McKirdy S. 2022

Double-layer biodegradable temporising matrix reconstruction for abdominal skin and soft-tissue reconstruction.

Wu S, Wells M, Ascha M, Duggal R, Gatherwright J, Chepla K. 2022

Head and neck wound reconstruction using Biodegradable Temporizing Matrix versus collagen-chondroitin silicone bilayer.

Teo TS, Crawford LC, Pilch WT, Carney B, Solanki N, Kidd SE, Warner MS. 2021

Mycetoma caused by Microsporum canis in a patient with renal transplant: A case report and review of the literature

Li H, Lim P, Stanley E, Lee G, Lin S, Neoh D, Liew J, Ng SK. 2021

Experience with NovoSorb^® Biodegradable Temporising Matrix in reconstruction of complex wounds.

Frost SR, Deodhar A, Offer GJ. 2022

A novel use for the biodegradable temporizing matrix

Wu-Fienberg Y, Wu SS, Gatherwright J, Chepla KJ. 2021

An alternative dermal template for reconstruction of complex upper extremity wounds.

Pontell ME, Niklinska E, Bonfield CM, Golinko MS. 2022

Management of an open nasofrontal encephalocele during the first day of life.

Dastagir K, Obed D, Bucher F, Hofmann T, Koyro KI, Vogt PM. 2021

Non-invasive and surgical modalities for scar management: A clinical algorithm.

Wagstaff MJD, Schmitt B, Caplash Y, Greenwood JE. 2015

Free flap donor site reconstruction: A prospective case series using an optimized polyurethane Biodegradable Temporizing Matrix.

Concannon E, Damkat-Thomas L, Rose E, Coghlan P, Solanki N, Wagstaff M. 2023

Use of a synthetic dermal matrix for reconstruction of 55 patients with non-graftable wounds and management of complications.

Wagstaff MJD, Salna IM, Caplash Y, Greenwood JE. 2019

Biodegradable Temporising Matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: A case series.

Schlottmann et al. 2022

Treatment of complex wounds with NovoSorb Biodegradable Temporizing Matrix: A retrospective analysis of clinical outcomes.

ALNafisee D, Casey MC, Kelly JL. 2022

Use of a synthetic biodegradable temporising matrix after necrotising fasciitis infection of the thigh.

Lim P, Li H, Ng S. 2023

NovoSorb^® Biodegradable Temporising Matrix (BTM) and its applications

Jennings M, Willet J, Coghlan P, Solanki NS. 2021

Biodegradable temporising matrix in severe meningococcal septicaemia: a case report.

Storey K, Lalloz M, Choy K-T, McBride CA, McMillan C, Das Gupta R, Patel B, Choo K, Stefanutti G, Borzi P, Phua Y, Bade S, Griffin B, Kimble RM. 2023

The versatility of Biodegradable Temporising Matrix – A 63 paediatric case series with complex wounds.

Sreedharan S, Morrison E, Cleland H, Ricketts S, Bruscino-Raiola F. 2019

Biodegradable Temporising Matrix for necrotising soft tissue infections: a case report.

Concannon E, Damkat-Thomas L, Rose E, Coghlan P, Solanki N, Wagstaff M. 2023

Use of a synthetic dermal matrix for reconstruction of 55 patients with non-graftable wounds and management of complications.

Barker T, Wagstaff M, Ricketts S, Bruscino-Raiola F. 2022

Use of a bilayer biodegradable synthetic dermal matrix for the management of defects arising from necrotising fasciitis.

Ray K, Khajoueinejad N, Park S, Chan M, Lee J, Lantis JC. 2021

The evidence for antimicrobial and hard to infect regenerative matrices.

Wagstaff MJD, Caplash Y, Greenwood JE. 2017

Reconstruction of an anterior cervical necrotizing fasciitis defect using a biodegradable polyurethane dermal substitute.

Li H, Lim P, Stanley E, Lee G, Lin S, Neoh D, Liew J, Ng SK. 2021

Experience with NovoSorb^® Biodegradable Temporising Matrix in reconstruction of complex wounds.

Malkoc A, Wong DT, Woodward B. 2022

Single staged treatment of a complex full thickness debridement for Hidradenitis Suppurativa using NovoSorb Biodegradable Temporizing Matrix.

Solanki NS, York B, Gao Y, Baker P, Wong She RB. 2020

A consecutive case series of defects reconstructed using NovoSorb^® Biodegradable Temporising Matrix: Initial experience and early results.

Guerriero FP, Clark RA, Miller M, Delaney CL. 2023

Overcoming barriers to wound healing in a neuropathic and neuro-ischaemic diabetic foot cohort using a novel bilayer biodegradable synthetic matrix.

Ray K, Khajoueinejad N, Park S, Chan M, Lee J, Lantis JC. 2021

The evidence for antimicrobial and hard to infect regenerative matrices.

Kuang B, Pena G, Cowled P, Fitridge R, Greenwood J, Wagstaff M, Dawson J. 2022

Use of Biodegradable Temporising Matric (BTM) in the reconstruction of diabetic foot wounds: A pilot study.

Cheng C, Kwiecien GJ, Rowe DJ, Gatherwright JR, Chepla KJ. 2021

Reconstruction of chronic wounds secondary to injectable drug use with a Biodegradable Temporizing Matrix.

Cao Y, Dominic W, Knezevich S, Kochubey M. 2022

Multiple leg wounds in an obese female with normal renal function.

Li H, Lim P, Stanley E, Lee G, Lin S, Neoh D, Liew J, Ng SK. 2021

Experience with NovoSorb^® Biodegradable Temporising Matrix in reconstruction of complex wounds.

MacDiarmid et al. 2022

Biodegradable Temporising Matrix for lower limb reconstruction following the resection of giant Marjolin’s ulcer.

Damkat-Thomas et al. 2019

A synthetic Biodegradable Temporizing Matrix in degloving lower extremity trauma reconstruction: A case report.

Jennings M, Willet J, Coghlan P, Solanki NS, Greenwood JE. 2021

Biodegradable temporising matrix in severe meningococcal septicaemia: a case report. Australasian Journal of Plastic Surgery.

Sun L, Cox S, Tan EK. 2021

Radiotherapy for wound treated with BTM: A case report and review of literature.

Concannon E, Damkat-Thomas L, Rose E, Coghlan P, Solanki N, Wagstaff M. 2023

Use of a synthetic dermal matrix for reconstruction of 55 patients with non-graftable wounds and management of complications.

Sun L, Tan E. 2021

Neglected cutaneous skin malignancy: A patient with concurrent giant basal cell carcinoma and melanoma.

Wu SS, Wells M, Ascha M, Gatherwright J, Chepla K. 2022

Performance of Biodegradable Temporizing Matrix vs collagen-chondroitin silicone bilayer dermal regeneration substitutes in soft tissue wound healing: a retrospective analysis.

Shah R, Kiely A, McKirdy S. 2022

Double-layer biodegradable temporising matrix reconstruction for abdominal skin and soft-tissue reconstruction.

Li H, Lim P, Stanley E, Lee G, Lin S, Neoh D, Liew J, Ng SK. 2021

Experience with NovoSorb^® Biodegradable Temporising Matrix in reconstruction of complex wounds.

MacDiarmid S, Butler D. 2022

Biodegradable Temporising Matrix for lower limb reconstruction following the resection of giant Marjolin’s ulcer.

Solanki NS, York B, Gao Y, Baker P, Wong She RB. 2020

A consecutive case series of defects reconstructed using NovoSorb^® Biodegradable Temporising Matrix: Initial experience and early results.

Lim P, Li H, Ng S. 2023

NovoSorb^® Biodegradable Temporising Matrix (BTM) and its applications. Surgical Technology International.

Guerriero FP, Clark RA, Miller M, Delaney CL. 2023

Overcoming barriers to wound healing in a neuropathic and neuro-ischaemic diabetic foot cohort using a novel bilayer biodegradable synthetic matrix.

Storey K, Lalloz M, Choy K-T, McBride CA, McMillan C, Das Gupta R, Patel B, Choo K, Stefanutti G, Borzi P, Phua Y, Bade S, Griffin B, Kimble RM. 2023

The versatility of Biodegradable Temporising Matrix – A 63 paediatric case series with complex wounds.

Kuang B, Pena G, Cowled P, Fitridge R, Greenwood J, Wagstaff M, Dawson J. 2022

Use of Biodegradable Temporising Matric (BTM) in the reconstruction of diabetic foot wounds: A pilot study.

Schlottmann et al. 2022

Treatment of complex wounds with NovoSorb Biodegradable Temporizing Matrix: A retrospective analysis of clinical outcomes.

Young CA, Semple HK, Kode GM. 2022

Complex wound healing in a complex patient.

Cao Y, Dominic W, Knezevich S, Kochubey M. 2022

Multiple leg wounds in an obese female with normal renal function.

Semple HK, Young C, Kode G.2022

Secondary healing over NovoSorb^® biodegradable temporising matrix (BTM) in the unwell patient: a case report. Australasian Journal of Plastic Surgery.

Ray K, Khajoueinejad N, Park S, Chan M, Lee J, Lantis JC. 2021

The evidence for antimicrobial and hard to infect regenerative matrices.

Guerriero FP, Delaney CL 2022

A prospective single centre case series on the use of epidermal grafts and adjunct technologies to facilitate wound healing in a vascular surgical patient population.

Cheng C, Kwiecien GJ, Rowe DJ, Gatherwright JR, Chepla KJ. 2021

Reconstruction of chronic wounds secondary to injectable drug use with a Biodegradable Temporizing Matrix.

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Clinical Index

Insights from your peers

Literature Review

Table 1: NovoSorb BTM Publication Growth

New Standard Results:

Table 2: NovoSorb BTM Scar Assessment

Clinical Summary of Select Publications

Author/Year

Description

Wounds Evaluated

Trauma

Reconstruction

Soft Tissue Infection

Chronic Wounds

Cancer Resection

Pressure Wounds

Limb Salvage

Donor Site

Exposed Bone/Tendon

Upper Extremity

Lower Extremity

Head/Neck

Trunk

Key Findings

Author/Year

Description

Wounds Evaluated

Trauma

Reconstruction

Soft Tissue Infection

Chronic Wounds

Cancer Resection

Pressure Wounds

Limb Salvage

Donor Site

Exposed Bone/Tendon

Upper Extremity

Lower Extremity

Head/Neck

Trunk

Key Findings

Author/Year

Description

Wounds Evaluated

Trauma

Reconstruction

Soft Tissue Infection

Chronic Wounds

Cancer Resection

Pressure Wounds

Limb Salvage

Donor Site

Exposed Bone/Tendon

Upper Extremity

Lower Extremity

Head/Neck

Trunk

Key Findings

Author/Year

Description

Wounds Evaluated

Trauma

Reconstruction

Soft Tissue Infection

Chronic Wounds

Cancer Resection

Pressure Wounds

Limb Salvage

Donor Site

Exposed Bone/Tendon

Upper Extremity

Lower Extremity

Head/Neck

Trunk

Key Findings

Author/Year

Description

Wounds Evaluated

Trauma

Reconstruction